CLINICAL STUDY CDKN1B V109G polymorphism a new prognostic factor in sporadic medullary thyroid carcinoma
نویسندگان
چکیده
Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale ‘F. Magrassi e A. Lanzara’, Seconda Università di Napoli, 80131 Napoli, Italy, Dipartimento di Scienze Biologiche ed Ambientali, Università degli Studi del Sannio, Via Port’Arsa, 82100 Benevento, Italy, e CEINGE SCARL, Biotecnologie Avanzate, 80131 Napoli, Italy, IRCCS Fondazione SDN, 80121 Napoli, Italy, Dipartimento di Endocrinologia e Metabolismo, Università di Pisa, 56124 Pisa, Italy, A. O. ‘A. Cardarelli’, VI Chirurgia, 80131 Napoli, Italy, Dipartimento di Medicina Interna e Endocrinologia, Università di Perugia, 06100 Perugia, Italy, Unità di Endocrinologia, ‘S. Maria della Misericordia’ Ospedale di Udine, 33100 Udine, Italy and Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Facoltà di Medicina e Chirurgia, Università ‘Federico II’, 80131 Napoli, Italy
منابع مشابه
CDKN1B V109G polymorphism a new prognostic factor in sporadic medullary thyroid carcinoma.
CONTEXT CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancreatic tumors. Association of CDNK1B mutations or polymorphisms with sporadic ...
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Germline mutations in p27(kip1) are associated with increased susceptibility to multiple endocrine neoplasias (MEN) both in rats and humans; however, the potential role of common polymorphisms of this gene in endocrine tumor susceptibility and tumorigenesis remains mostly unrecognized. To assess the risk associated with polymorphism rs2066827 (p27-V109G), we genotyped a large cohort of Brazilia...
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PURPOSE The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. METHODS We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. RESULTS In all, 65 patients (76.5%) had sporadic MTC and 20 patients (...
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CDKN1B encodes the cyclin-dependent kinase inhibitor p27/Kip1. CDKN1B mutations and polymorphisms are involved in tumorigenesis; specifically, the V109G single nucleotide polymorphism has been linked to different tumours with controversial results. Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant syndrome, characterized by the development of different types of neuroendocr...
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Thyroid cancer is a malignancy of the thyroid parenchymal cells. There are four main types of thyroid cancer: papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), anaplastic thyroid carcinoma (ATC), and Medullary thyroid carcinoma (MTC). Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor of the thyroid gland derived from parafollicular C-cells that produce calcitonin (CT...
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